Bryce Manifold

Effects of biological fixation methods on stimulated Raman scattering microscopy signal

This study examines how different fixation methods affect SRS microscopy signals in HeLa cells, finding that Paraformaldehyde causes less disruption than other fixatives.

SRS microscopy identifies inhibition of vitellogenesis as a mediator of lifespan extension by caloric restriction in C. elegans

The paper uses SRS microscopy to show caloric restriction extends C. elegans lifespan by inhibiting vitellogenesis, a process linked to protein buildup in the pseudocoelom.

In Vivo Simultaneous Nonlinear Absorption Raman and Fluorescence (SNARF) Imaging of Mouse Brain Cortical Structures

This study introduces a SNARF microscope combining SRS and TAM for in vivo brain imaging, achieving high depth and enabling label-free analysis of cortical structures and cell identities.