HPV16 E2 protein possesses intrinsic helicase activity and sterically hinders E1 function through direct interaction
Ping Xu, Shuning Cai, Lihong Zhang, Yueqi Wu, Ke Xu, Yigang Tong, Shan Xu
This paper identifies intrinsic ATP-dependent helicase activity in HPV16 E2 protein, identifies key residues for this activity, and shows E2 inhibits E1 helicase through direct interaction.
Journal of Biological Chemistry · May 20, 2026Peer-reviewedMolecular Biology