Yueqi Wu

This study shows that manganese ions inhibit influenza A virus replication by targeting the PA endonuclease, reducing viral mRNA synthesis and improving survival in a mouse model.

This paper identifies intrinsic ATP-dependent helicase activity in HPV16 E2 protein, identifies key residues for this activity, and shows E2 inhibits E1 helicase through direct interaction.

The paper identifies the C-terminal domain of influenza A virus PA protein as the active center for endonuclease activity and a novel antiviral target, revealing potential drug resistance mutations and new inhibitors.