Yigang Tong

This study shows that manganese ions inhibit influenza A virus replication by targeting the PA endonuclease, reducing viral mRNA synthesis and improving survival in a mouse model.

This paper organizes a community challenge to develop automated virus taxonomy classification tools and evaluates their performance on a combined dataset of expert-curated and metagenomic sequences.

This paper identifies intrinsic ATP-dependent helicase activity in HPV16 E2 protein, identifies key residues for this activity, and shows E2 inhibits E1 helicase through direct interaction.

The paper identifies the C-terminal domain of influenza A virus PA protein as the active center for endonuclease activity and a novel antiviral target, revealing potential drug resistance mutations and new inhibitors.

The paper identifies a new family of RiPPs in lactic acid bacteria biosynthetic gene clusters, revealing a novel adenylyltransferase mechanism for macrocyclic imide formation.

This study expands the number of complete temperate phage genomes by over 100-fold using a novel computational method applied to bacterial NGS data.

The paper identifies potential drug targets for Mycobacterium chelonae using subtractive genomics and performs virtual screening of phytochemicals to find compounds that bind to GlmU, a druggable protein.

The paper analyzes codon usage patterns in Zika virus strains to infer evolutionary origins and adaptation strategies, linking findings to Aedes population data in the Americas.