H. Efsun Arda

This study identifies rs9581943 as a causal variant in a PDAC GWAS signal, showing it reduces PDX1 expression and impairs stress buffering in exocrine pancreatic cells.

The paper develops a method to prioritize enhancers linked to pancreas disease risk by integrating chromatin interactions, machine learning, and single-cell perturbation assays.

This study shows that Hippo pathway-mediated YAP1/TAZ inhibition is essential for pancreatic endocrine specification and differentiation, but not for beta-cell function.

The paper analyzes single-cell transcriptome and chromatin accessibility data to uncover transcription factor networks governing pancreatic endocrine cell lineage specification.

The paper identifies a transcriptionally distinct subpopulation of healthy acinar cells with features of pancreatic progenitors and PDAC, linked to poor patient survival and age-related changes.

This study uses single-cell RNA-seq to analyze human pancreatic cells across age, identifying transcriptional instability and age-related mutational signatures linked to oxidative stress.