Author

Jacob C. Zbesko

University of ArizonaORCID 0000-0002-5298-4254Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Danielle A. BeckteliD· 3 shared Kristian P. DoyleiD· 3 shared Thuy‐Vi V. NguyeniD· 3 shared Amanda G. Chung· 2 shared Frankie G. GarciaiD· 2 shared Jennifer Beischel Frye· 2 shared Kylie Calderon· 2 shared Marco A. Tavera-Garcia· 2 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersNeuroscience

Danielle A. BecktelORCID

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3 papers

Recent·Most cited

NeuroscienceJournal of Pharmacology and Experimental TherapeuticsPeer-reviewedDec 10, 2021

Post-stroke administration of the p75 neurotrophin receptor modulator, LM11A-31, attenuates chronic changes in brain metabolism, increases neurotransmitter levels, and improves recovery

Thuy‐Vi V. Nguyen, Rachel H. Crumpacker, Kylie Calderon…·Kristian P. Doyle

This study shows that LM11A-31, a p75NTR modulator, improves stroke recovery by enhancing brain metabolism, neurotransmitter levels, and reducing neurodegeneration in mice.

15 citations

mousestatistical model

𝕏 PostBluesky

NeuroscienceJournal of NeurosciencePeer-reviewedNov 24, 2021

Repeated administration of 2-hydroxypropyl-β-cyclodextrin (HPβCD) attenuates the chronic inflammatory response to experimental stroke

Danielle A. Becktel, Jacob C. Zbesko, Jennifer B. Frye…·Kristian P. Doyle

This study shows that repeated HPβCD treatment reduces chronic inflammation and cognitive decline after stroke by modulating lipid metabolism and immune responses.

40 citations

mousebulk RNA-seq

𝕏 PostBluesky

NeuroscienceeNeuroPeer-reviewedSep 1, 2018

Liquefaction of the brain following stroke shares a similar molecular and morphological profile with atherosclerosis and mediates secondary neurodegeneration in an osteopontin dependent mechanism

Amanda G. Chung, Jennifer Beischel Frye, Jacob C. Zbesko…·Kristian P. Doyle

This paper compares ischemic inflammation in the heart and brain, finding a second inflammatory wave in the brain post-stroke linked to cholesterol crystals and osteopontin, which drives secondary neurodegeneration.

52 citations

mouseexperimental assay

𝕏 PostBluesky