Jennifer Beischel Frye

Neuroprotective activity of sub-anesthetic ketamine in a preclinical model of Parkinson's disease is not blocked by antagonizing brain-derived neurotrophic factor signaling

This study shows that low-dose ketamine protects against Parkinson's-like motor deficits in rats without relying on BDNF-TrkB signaling.

ABERRANT HIPPOCAMPAL NEUROGENESIS IS A CONSERVED RESPONSE TO STROKE IN MICE: A MULTI-CENTER MULTIMODEL STUDY

This study shows that stroke increases hippocampal neurogenesis but leads to maladaptive morphological features in newborn neurons across multiple mouse stroke models.

Assessing post-stroke cognition in pre-clinical models: lessons and recommendations from a multi-center study

This study evaluates cognitive outcomes after stroke in mice using multiple models and tests, finding inconsistent results and highlighting challenges in pre-clinical stroke cognition research.

Cognitive dysfunction following brain trauma results from sex-specific reactivation of the developmental pruning processes

This study identifies a sex-specific reactivation of developmental pruning processes as a cause of cognitive dysfunction after brain trauma and shows the pathway is reversible.

Manual lymph drainage massage of the head and neck improves cognition and reduces pathological biomarkers in the 5x-FAD mouse model of Alzheimers disease

This study shows that manual lymph drainage massage of the head and neck improves cognition and reduces Aβ and NfL levels in 5x-FAD mice.

Post-stroke administration of the p75 neurotrophin receptor modulator, LM11A-31, attenuates chronic changes in brain metabolism, increases neurotransmitter levels, and improves recovery

This study shows that LM11A-31, a p75NTR modulator, improves stroke recovery by enhancing brain metabolism, neurotransmitter levels, and reducing neurodegeneration in mice.

Liquefaction of the brain following stroke shares a similar molecular and morphological profile with atherosclerosis and mediates secondary neurodegeneration in an osteopontin dependent mechanism

This paper compares ischemic inflammation in the heart and brain, finding a second inflammatory wave in the brain post-stroke linked to cholesterol crystals and osteopontin, which drives secondary neurodegeneration.