VMAT2 dysfunction impairs vesicular dopamine uptake, driving its oxidation and α-synuclein pathology in DJ-1-linked Parkinson's disease neurons
Leonie M. Heger, Francesco Gubinelli, Andreas J. Huber, Aida Cardona‐Alberich, Matteo Rovere, Ulf Matti, Stephan A. Müller, Sankarshana R. Nagaraja, Lena Jaschkowitz, Martina Schifferer, Wolfgang Wurst, Stefan F. Lichtenthaler, Christian Behrends, Sivakumar Sambandan, Lena F. Burbulla
This study shows that DJ-1 deficiency impairs VMAT2 function and vesicle dynamics, leading to dopamine oxidation and α-synuclein pathology in Parkinson's disease neurons.
Science Advances · Feb 11, 2026Peer-reviewedNeuroscience