Crystal structures of glycoprotein D of equine alphaherpesviruses reveal potential binding sites to the entry receptor MHC-I
Viviane Kremling, Bernhard Loll, Szymon Pach, Ismail Dahmani, Christoph Weise, Gerhard Wolber, Salvatore Chiantia, M.C. Wahl, Nikolaus Osterrieder, Walid Azab
The paper determines the crystal structures of EHV-1 and EHV-4 glycoprotein D (gD) and identifies key residues critical for binding to MHC-I, providing insights for antiviral drug and vaccine development.
bioRxiv · Jun 10, 2022 · PreprintMolecular Biology