M.C. Wahl

Molecular mechanism of albicidin-dependent transcription activation by the antibiotic resistance factor AlbA

This study elucidates how AlbA, an antibiotic resistance factor, activates transcription in response to albicidin by remodeling promoter architecture and facilitating a kinetic transition to promoter opening.

The co-localizing Zorya II, Druantia III, and ARMADA II defense systems on O-island 172 confer synergistic anti-phage defense in enterohemorrhagic Escherichia coli

This study identifies that the co-localizing Zorya II, Druantia III, and ARMADA II defense systems on O-island 172 in EHEC confer synergistic anti-phage defense, with Druantia III and ARMADA II providing most of the phage resistance.

Regulatory landscapes and structural choreography of transcription initiation in spirochetes

This study investigates the transcription initiation mechanism in spirochetes, revealing unique structural and functional features of their RNA polymerase.

The Ski2 helicase ASCC3 unwinds DNA upon fork stalling to control replication stress responses

This study identifies ASCC3 as a helicase that unwinds DNA at stalled replication forks, promoting fork reversal and preventing genomic instability during replication stress.

Identification and characterization of a synaptic active zone assembly protein

This study identifies Blobby as a novel regulator of presynaptic active zone nanopatterning and shows its role in maintaining Ca2+ channel packing density and synaptic function.

Widespread gene regulator Psu inhibits transcription termination factor rho by forced hyper-oligomerization

Branch point evolution controls species-specific alternative splicing and regulates long term potentiation

The paper identifies primate-specific CAMK2B splice variants regulated by branch point weakening, showing their role in long-term potentiation and learning.

Crystal structures of glycoprotein D of equine alphaherpesviruses reveal potential binding sites to the entry receptor MHC-I

The paper determines the crystal structures of EHV-1 and EHV-4 glycoprotein D (gD) and identifies key residues critical for binding to MHC-I, providing insights for antiviral drug and vaccine development.

A human kinase yeast array for the identification of kinases modulating phosphorylation-dependent protein-protein interactions

The paper develops a human kinase yeast array to assess kinase activities and identify kinases modulating phosphorylation-dependent protein-protein interactions.

Intramolecular domain dynamics regulate synaptic MAGUK protein interactions

The paper shows that binding of PDZ3 ligands to PSD-95's third PDZ domain alters its SH3-GK domain conformation, affecting complex formation with interactors like Gnb5.