Author

Szymon Pach

Freie Universität BerlinORCID 0000-0001-6109-7123Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 1 Organism:human· 1 Assay:protein structure· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Gerhard WolberiD· 3 shared Valerij TalagayeviD· 2 shared A.M. EdwardsiD· 1 shared Aiping DongiD· 1 shared Akhila MettuiD· 1 shared Albina Bolotokova· 1 shared Aleksandra IvanováiD· 1 shared Alexander FürlliD· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiochemistry

Gerhard WolberORCID

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3 papers

Recent·Most cited

BiochemistryJournal of Chemical Information and ModelingPeer-reviewedNov 5, 2024

CACHE Challenge #1: targeting the WDR domain of LRRK2, a Parkinson's Disease associated protein.

Fengling Li, Suzanne Z. Ackloo, C. H. Arrowsmith…·Matthieu Schapira

The paper evaluates computational hit-finding methods for targeting the WDR domain of LRRK2, a Parkinson's disease protein, finding that diverse strategies yielded weakly potent compounds.

34 citationstop 4%

deep learningdrug response / drug discovery

𝕏 PostBluesky

Pharmacology & ToxicologyACS Medicinal Chemistry LettersPeer-reviewedOct 15, 2024

From Virtual Screens to Cellular Target Engagement: New Small Molecule Ligands for the Immune Checkpoint LAG-3

Natalie S. Fuchs, Laura Calvo‐Barreiro, Valerij Talagayev…·Moustafa Tarek Gabr

The paper identifies two small molecule ligands for LAG-3 through virtual screening and experimental validation, with one showing cellular target engagement.

13 citations

humanproteomics

𝕏 PostBluesky

Molecular BiologybioRxivPreprintJun 10, 2022

Crystal structures of glycoprotein D of equine alphaherpesviruses reveal potential binding sites to the entry receptor MHC-I

Viviane Kremling, Bernhard Loll, Szymon Pach…·Walid Azab

The paper determines the crystal structures of EHV-1 and EHV-4 glycoprotein D (gD) and identifies key residues critical for binding to MHC-I, providing insights for antiviral drug and vaccine development.

DOI 10.1101/2022.06.10.495596

protein structureexperimental assay

𝕏 PostBluesky