SARS-CoV-2 methyltransferase nsp10-16 in complex with natural and drug-like purine analogs for guiding structure-based drug discovery
Viviane Kremling, Sven Falke, Yaiza Fernández-García, Christiane Ehrt, Antonia Kiene, Bjarne Klopprogge, Emilie Scheer, Fabian Barthels, Philipp Middendorf, Sebastian Kühn, Stephan Günther, Matthias Rarey, Henry N. Chapman, Dominik Oberthür, Janina Sprenger
The paper identifies ligands binding to the SARS-CoV-2 nsp10-16 complex using X-ray crystallography and reports their structures, providing insights for drug discovery.
bioRxiv · Mar 13, 2024 · PreprintBiochemistry