Cancer BiologyMolecular TherapyPeer-reviewed
Soluble CTLA-4 raises the threshold for T-cell activation and modulates anti-tumour immunity
Paul T. Kennedy, Emma L. Saulters, Andrew David Duckworth…·Lekh N. Dahal
This study shows that soluble CTLA-4 suppresses T-cell activation and promotes tumor growth in mice, and that blocking sCTLA-4 enhances anti-tumor immunity.
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