Author

Lekh N. Dahal

University of LiverpoolORCID 0000-0001-8390-6593Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Catarina BritoiD· 1 shared Catarina Monteiro GomesiD· 1 shared Daniel F. SimãoiD· 1 shared Diana Duarte LoboiD· 1 shared Dimitris LagosiD· 1 shared Gabriela Priscila de Lima SilvaiD· 1 shared James R. BlackiD· 1 shared JEFF K. DAVIESiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBioengineering

Catarina BritoORCID

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2 papers

Recent·Most cited

BioengineeringbioRxivPreprintJul 7, 2025

Innate immunocompetent iNSpheroids: A hiPSC-derived 3D model to study the central nervous system captures an early CNS response to rAAV

Catarina Monteiro Gomes, Gabriela Priscila de Lima Silva, Mafalda M Aleixo…·Catarina Brito

The paper develops a 3D human CNS model from hiPSCs to study immune responses to rAAV gene therapy, finding that iMGL-iNSpheroids show mild, transient inflammation to rAAV9.

DOI 10.1101/2025.07.07.662807

humanspatial transcriptomics

𝕏 PostBluesky

Cancer BiologybioRxivPreprintFeb 6, 2025

LIMD1 Loss as an Early Driver of PD-L1 Upregulation and Immune Evasion in Lung Cancer

Kunal M. Shah, Paul T. Kennedy, James R. Black…·Tyson V. Sharp

This study shows that LIMD1 loss in lung cancer increases PD-L1 expression, promoting immune evasion and enhancing response to immune checkpoint inhibitors.

3 citations

humanbulk RNA-seq

𝕏 PostBluesky