The paper introduces PIXANT, a multi-phenotype imputation method that improves GWAS power by imputing 425 phenotypes for 277,301 individuals, leading to the discovery of 18.4% more GWAS loci.

Nature Communications · Jan 4, 2025Peer-reviewedBioinformatics

Ancient farmer and steppe pastoralist-related founding lineages contributed to the complex landscape of episodes in the diversification of Chinese paternal lineages

Mengge Wang, Yuguo Huang, Kaijun Liu, Haibing Yuan, Shuhan Duan, Zhiyong Wang, Lan‐Hai Wei, Hongbing Yao, Qiuxia Sun, Jie Zhong, Renkuan Tang, Jing Chen, Yuntao Sun, Xiangping Li, Haoran Su, , Guanglin He

The paper uses ancient DNA and genomic data to trace the genetic contributions of ancient farmer and steppe pastoralist lineages to the paternal genetic diversity of modern Chinese populations.

bioRxiv · Aug 28, 2023 · PreprintGenetics

Differentiated genomic footprints and connections inferred from 440 Hmong-Mien genomes suggest their isolation and long-distance migration

Guanglin He, Jing Chen, Yan Liu, Rong Hu, Peixin Wang, Shuhan Duan, Qiuxia Sun, Renkuan Tang, Junbao Yang, Zhiyong Wang, Xiaofei Xu, Yuntao Sun, Libing Yun, Liping Hu, Jiangwei Yan, , Mengge Wang

This study analyzes 440 Hmong-Mien genomes to reveal genetic differentiation, admixture, and migration patterns, supporting isolation and long-distance migration.

bioRxiv · Jan 14, 2023 · PreprintGenetics

The Chromosome-based Genome of Paspalum vaginatum Provides New Insights into Salt-stress Adaptation

Li Liao, Xu Wei Hu, Jiangshan Hao, Minqiang Tang, Longzhou Ren, Ling Pan, Shuang Xie, Paul L. Raymer, Qi Peng, Zhenbang Chen, Zhiyong Wang, Jie Luo

This study reports the chromosome-scale genome of Paspalum vaginatum, identifies salt tolerance-related genes, and shows their role in enhancing salt tolerance in Arabidopsis.

bioRxiv · Aug 8, 2022 · PreprintGenomics