NASTRA is a reference-free tool for STR genotyping using nanopore sequencing, achieving 100% accuracy in diploid STR analysis across multiple platforms.

Briefings in Bioinformatics · Sep 10, 2024Peer-reviewedBioinformatics

Distinguished biological adaptation architecture aggravated population differentiation of Tibeto-Burman-speaking people inferred from 500 whole genome data from 39 populations

Yuntao Sun, Mengge Wang, Qiuxia Sun, Yan Liu, Shuhan Duan, Zhiyong Wang, Yunyu Zhou, Zhong Jun, Yuguo Huang, Xinyu Huang, Qingxin Yang, Xiangping Li, Haoran Su, Yan Cai, Xiucheng Jiang, , Guanglin He

The paper analyzes 500 whole genomes from 39 Tibeto-Burman populations to uncover genetic differentiation and adaptive features linked to geography and environment.

Journal of genetics and genomics/Journal of Genetics and Genomics · Oct 11, 2023Peer-reviewedGenetics

Ancient farmer and steppe pastoralist-related founding lineages contributed to the complex landscape of episodes in the diversification of Chinese paternal lineages

Mengge Wang, Yuguo Huang, Kaijun Liu, Haibing Yuan, Shuhan Duan, Zhiyong Wang, Lan‐Hai Wei, Hongbing Yao, Qiuxia Sun, Jie Zhong, Renkuan Tang, Jing Chen, Yuntao Sun, Xiangping Li, Haoran Su, , Guanglin He

The paper uses ancient DNA and genomic data to trace the genetic contributions of ancient farmer and steppe pastoralist lineages to the paternal genetic diversity of modern Chinese populations.

bioRxiv · Aug 28, 2023 · PreprintGenetics

Malaria resistance-related biological adaptation and complex evolutionary footprints of Tai-Kadai people inferred from 796 genomes

Shuhan Duan, Mengge Wang, Zhiyong Wang, Yan Liu, Xiucheng Jiang, Haoran Su, Yan Cai, Qiuxia Sun, Yuntao Sun, Xiangping Li, Jing Chen, Yijiu Zhang, Jiangwei Yan, Shengjie Nie, Liping Hu, , Guanglin He

This study analyzes 796 Tai-Kadai genomes to uncover genetic adaptations and evolutionary history, revealing Malaria resistance and population structure in TK-speaking groups.

bioRxiv · Jul 4, 2023 · PreprintGenetics

Whole-genome sequencing of ethnolinguistic diverse northwestern Chinese Hexi Corridor people from the 10K_CPGDP project suggested the differentiated East-West genetic admixture along the Silk Road and their biological adaptations

Guanglin He, Hongbing Yao, Qiuxia Sun, Shuhan Duan, Renkuan Tang, Jing Chen, Zhiyong Wang, Yuntao Sun, Xiangping Li, Shaomei Wang, Liping Hu, Libing Yun, Junbao Yang, Jiangwei Yan, Shengjie Nie, , Mengge Wang

The paper uses whole-genome sequencing of 126 individuals from six ethnolinguistic groups in Northwest China to study genetic admixture and biological adaptations along the Silk Road.

bioRxiv · Feb 26, 2023 · PreprintGenomics

Differentiated genomic footprints and connections inferred from 440 Hmong-Mien genomes suggest their isolation and long-distance migration

Guanglin He, Jing Chen, Yan Liu, Rong Hu, Peixin Wang, Shuhan Duan, Qiuxia Sun, Renkuan Tang, Junbao Yang, Zhiyong Wang, Xiaofei Xu, Yuntao Sun, Libing Yun, Liping Hu, Jiangwei Yan, , Mengge Wang

This study analyzes 440 Hmong-Mien genomes to reveal genetic differentiation, admixture, and migration patterns, supporting isolation and long-distance migration.

bioRxiv · Jan 14, 2023 · PreprintGenetics

The construction and application of a new 17-plex Y-STR system using universal fluorescent PCR

Jinding Liu, Rongshuai Wang, Jie Ru Shi, Xiaojuan Cheng, Ting Hao, Jiangling Guo, Jiaqi Wang, Zidong Liu, Wenyan Li, Haoliang Fan, Keming Yun, Jiangwei Yan, Gengqian Zhang

This paper develops a 17-plex Y-STR system with high discrimination power for human identification and genealogy searching.

International Journal of Legal Medicine · Apr 22, 2020Peer-reviewedGenetics