Author

Sarah E. Ewald

University of VirginiaORCID 0000-0002-5327-7578Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1 Assay:proteomics· 1 Approach:statistical model· 1 Organism:virus· 1

Frequent Co-Authors

A. Chaudhry· 1 shared B. Nichols· 1 shared Caitlyn E. MiddletoniD· 1 shared Eli V. Casarez· 1 shared J ArroyoiD· 1 shared L. F. Fitzsimmons· 1 shared Laura‐Isobel McCalliD· 1 shared Mahbobeh LesaniiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperMicrobiology

A. Chaudhry

Mutual co-authors in cluster

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2 papers

Recent·Most cited

MicrobiologymSpherePeer-reviewedJun 30, 2026

Cysteine-S-nitrosylation inhibits Rop5-mediated immune evasion in Toxoplasma gondii

Samantha L. Lempke, P. DiMare, B. Nichols…·Sarah E. Ewald

This study shows that RNS inhibit ROP5-mediated immune evasion in Toxoplasma gondii by modifying ROP5 through S-nitrosylation, reducing its association with the parasitophorous vacuole membrane.

3 citationstop 1%

mousevirus

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MicrobiologymSystemsPeer-reviewedNov 6, 2025

Spatially-divergent metabolic impact of experimental toxoplasmosis: immunological and microbial correlates

Mahbobeh Lesani, Caitlyn E. Middleton, Tzu-Yu Feng…·Laura‐Isobel McCall

This study examines metabolic changes in multiple tissues during toxoplasmosis, finding that immune responses, not parasite burden, drive metabolic perturbations in chronic infection.

3 citations

mousebulk RNA-seq

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