Midkine Dependency Defines a Therapeutically Actionable Vulnerability in Medulloblastoma
Sridharan Jayamohan, Prabhakar Pitta Venkata, Jessica D. Johnson, Baskaran Subramani, Nour E Abdelfattah, Yi Zou, Zhao Lai, Shayla A Hernandez, Panneerdoss Subbarayalu, Uday P. Pratap, Siyuan Zheng, Manjeet K. Rao, Andrew Jacob Brenner, Suryavathi Viswanadhapalli, Ratna K. Vadlamudi, , Gangadhara R. Sareddy
This study identifies midkine (MDK) as a critical regulator of medulloblastoma growth and survival, showing that its suppression reduces tumor growth and prolongs survival in xenograft models.
bioRxiv · Apr 14, 2026 · PreprintCancer Biology