Nicholas Graham

The paper identifies metabolically distinct groups using genetic overlap between schizophrenia and cardiometabolic disease in two cohorts.

This study identifies 11 novel genome-wide significant loci for anhedonia, finds genetic correlations with major depressive disorder, schizophrenia, and bipolar disorder, and shows polygenic associations with brain structure.

This paper conducts a GWAS of mood instability in 363,705 UK Biobank participants, identifies 46 loci, and finds genetic correlations with psychiatric disorders and brain-specific gene expression.

This paper identifies three novel genome-wide significant loci for suicidality using UK Biobank data and finds strong genetic correlations with depression and increased polygenic risk for completed suicide.

This study evaluates polygenic risk scores for MDD and neuroticism as predictors of antidepressant response across three cohorts, finding no significant prediction but consistent directional effects.

This study identifies genetic loci associated with circadian rhythmicity using UK Biobank data and finds polygenic associations with mood instability and major depressive disorder.

This study identifies genetic loci associated with risk-taking behavior and finds shared genetic risk with several psychiatric and physical disorders using UK Biobank data.

This study identifies 9 new genetic loci associated with neuroticism using genome-wide data from over 106,000 individuals.