Rona J. Strawbridge

This study identifies shared genetic loci between chronic pain and depression using genome-wide association data, revealing potential molecular mechanisms underlying their comorbidity.

This study shows that disrupting non-canonical autophagy (LANDO) impairs endothelial and cardiac function by disrupting VEGFR2 recycling and Hb- expression.

This study characterizes MDD subgroups based on weight and sleep changes, finding distinct clinical and genetic profiles, including novel associations with epilepsy and immunometabolic genes.

This paper conducts a genome-wide association study of happiness, identifying genetic loci and correlations with personality traits, and shows consistent genetic effects across age and ancestry.

This study identifies 592 genetic loci associated with 184 plasma proteins in 26,494 individuals and finds causal relationships between protein levels and disease.

This study performs a GWAS on random glucose measurements in 493,036 individuals, identifying 128 loci associated with glycaemic traits and providing insights into diabetes biology and treatment.

This study conducts a sex-stratified genome-wide association study of multisite chronic pain in UK Biobank, identifying sex-specific genetic loci and highlighting sex differences in chronic pain mechanisms.

The paper identifies metabolically distinct groups using genetic overlap between schizophrenia and cardiometabolic disease in two cohorts.

The paper investigates associations between APOE genotypes and blood biomarkers in UK Biobank, finding both expected and unexpected links to AD risk factors.

This study identifies 11 novel genome-wide significant loci for anhedonia, finds genetic correlations with major depressive disorder, schizophrenia, and bipolar disorder, and shows polygenic associations with brain structure.

This study identifies 11 novel SNPs associated with chronic pain and MDD using cFDR analysis, finding pleiotropy involving LRFN5 and other genes.

The paper identifies genetic variants and transcripts associated with glycemic traits by analyzing exome-array data from 144,600 individuals, highlighting tissue-specific roles in glucose regulation.

This study conducts a genome-wide association study of Multisite Chronic Pain in UK Biobank, identifying genetic variants and pathways associated with chronic pain.

This paper conducts a GWAS of mood instability in 363,705 UK Biobank participants, identifies 46 loci, and finds genetic correlations with psychiatric disorders and brain-specific gene expression.

This paper identifies three novel genome-wide significant loci for suicidality using UK Biobank data and finds strong genetic correlations with depression and increased polygenic risk for completed suicide.

This study evaluates polygenic risk scores for MDD and neuroticism as predictors of antidepressant response across three cohorts, finding no significant prediction but consistent directional effects.

This study identifies genetic loci associated with circadian rhythmicity using UK Biobank data and finds polygenic associations with mood instability and major depressive disorder.

This study identifies genetic loci associated with risk-taking behavior and finds shared genetic risk with several psychiatric and physical disorders using UK Biobank data.

The paper examines the association between APOE e4 genotype and brain structural ageing phenotypes in UK Biobank, finding a significant link with white matter hyperintensity volumes but no age interaction.

This study identifies 6 new blood pressure loci and 48 genes involved in BP regulation using GWAS and gene expression data from blood and kidney tissues.