Elizabeth M. Tunbridge

The paper investigates a human-specific VNTR in CACNA1C and shows it modulates neuronal calcium responses and transcription programs.

The paper uses long-read sequencing to identify novel isoforms and splicing regulators during neuronal differentiation in human neuroblastoma cells.

This study investigates how dopamine clearance mechanisms, DAT and COMT, affect behavioral flexibility in mice using pharmacological modulation and behavioral tasks.

The paper uses long-read sequencing to uncover the complex splicing profile of the CACNA1C gene in human brain, identifying numerous novel exons and transcripts with potential functional implications.

This paper conducts a GWAS of mood instability in 363,705 UK Biobank participants, identifies 46 loci, and finds genetic correlations with psychiatric disorders and brain-specific gene expression.

This study identifies genetic loci associated with risk-taking behavior and finds shared genetic risk with several psychiatric and physical disorders using UK Biobank data.