Amy Ferguson

The paper examines rare variants in monogenic cerebral small vessel disease genes in UK Biobank participants, finding limited phenotype associations and suggesting issues with previous gene-phenotype links.

The paper identifies rare variants in HTRA1 and its substrate EGFL8 associated with increased white matter hyperintensities using whole-exome sequencing data from 16,511 UK Biobank individuals.

The paper identifies metabolically distinct groups using genetic overlap between schizophrenia and cardiometabolic disease in two cohorts.

The paper investigates associations between APOE genotypes and blood biomarkers in UK Biobank, finding both expected and unexpected links to AD risk factors.

This study identifies 11 novel genome-wide significant loci for anhedonia, finds genetic correlations with major depressive disorder, schizophrenia, and bipolar disorder, and shows polygenic associations with brain structure.

This study conducts a genome-wide association study of Multisite Chronic Pain in UK Biobank, identifying genetic variants and pathways associated with chronic pain.

This paper conducts a GWAS of mood instability in 363,705 UK Biobank participants, identifies 46 loci, and finds genetic correlations with psychiatric disorders and brain-specific gene expression.

This paper identifies three novel genome-wide significant loci for suicidality using UK Biobank data and finds strong genetic correlations with depression and increased polygenic risk for completed suicide.

This study evaluates polygenic risk scores for MDD and neuroticism as predictors of antidepressant response across three cohorts, finding no significant prediction but consistent directional effects.

This study identifies genetic loci associated with circadian rhythmicity using UK Biobank data and finds polygenic associations with mood instability and major depressive disorder.

This study identifies genetic loci associated with risk-taking behavior and finds shared genetic risk with several psychiatric and physical disorders using UK Biobank data.