Deep Proteoform Sequencing with Top-Down Direct Mass Technology
Kenneth R. Durbin, Taojunfeng Su, Ryan T. Fellers, John P. McGee, Nickolas P. Fisher, Michael A. R. Hollas, Jared O. Kafader, Neil L. Kelleher
This paper introduces a top-down mass spectrometry workflow with DMTm technology and a new software platform to achieve deeper proteoform sequencing and improved sequence coverage.
bioRxiv · Jun 3, 2026 · PreprintBioinformatics