Author

Rachel M. Johnson

University of LeedsORCID 0000-0002-5363-837XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

David J. BeechiD· 1 shared David J. WrightiD· 1 shared Katie J. SimmonsiD· 1 shared Robin S. BoniD· 1 shared Stephen P. MuenchiD· 1 shared

Activity by Year

2020-2020 · peak 1/yr

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5 top collaborators · 10 mutual co-author links

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1 shared paperMolecular Biology

David J. BeechORCID

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1 paper

Recent·Most cited

Molecular BiologyCommunications BiologyPeer-reviewedNov 23, 2020

Cryo-EM structures of human TRPC5 reveal interaction of a xanthine-based TRPC1/4/5 inhibitor with a conserved lipid binding site.

David J. Wright, Katie J. Simmons, Rachel M. Johnson…·Robin S. Bon

The paper reports the cryo-EM structure of human TRPC5 bound to the xanthine inhibitor Pico145, revealing its interaction with a conserved lipid binding site and elucidating the mechanism of TRPC1/4/5 modulation.

67 citations

humanexperimental assay

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