An ERK5-KLF2 signalling module regulates early embryonic gene expression dynamics and stem cell rejuvenation
Helen A. Brown, Charles A.C. Williams, Houjiang Zhou, Diana Rios-Szwed, Rosalia Fernandez-Alonso, Saria Mansoor, Liam McMulkin, Rachel Toth, Robert Gourlay, Julien Peltier, Nora Diéguez-Martínez, Matthias Trost, José Miguel Lizcano, Marios P. Stavridis, Greg M. Findlay
This study identifies an ERK5-KLF2 signalling module that regulates 2C gene expression and mESC rejuvenation through both transcriptional activation and phosphorylation-induced degradation of KLF2.
Biochemical Journal · Nov 15, 2021Peer-reviewedDevelopmental Biology