Greg M. Findlay

Phosphorylation enables progressive microtubule-associated protein proteolysis and functionalisation during neural development

The paper identifies SRPK-mediated phosphorylation of MAP1S, showing it regulates proteolytic processing and microtubule binding during neurodevelopment.

Proteomic and functional comparison between human induced and embryonic stem cells

This study compares the proteomes of human induced pluripotent stem cells (hiPSCs) and embryonic stem cells (hESCs), finding quantitative differences in protein expression affecting growth, metabolism, and secreted factors.

The ERK5 MAP kinase regulates annexin complexes and membrane dynamics in embryonic stem cells

The paper identifies ERK5's role in regulating Annexin A2/S100A10 complex and membrane dynamics in mESCs through transcriptional induction of KLF2.

Asymmetric cell division-specific phosphorylation of PAR-3 regulates neuroblasts polarisation and sensory organ formation in Drosophila

This study shows that CDK1 phosphorylates PAR-3 in asymmetrically dividing cells, affecting polarity and fate determination in Drosophila neuroblasts and sensory organ precursors.

Engineering fluorescent reporters in human pluripotent cells and strategies for live imaging human neurogenesis

The paper develops fluorescent reporter tools in human pluripotent stem cells to study neural development through live imaging of cell behaviors.

Cell autonomous requirement of imprinted XCI inextra-embryonic polar trophoblast cells

The paper investigates the role of imprinted XCI in polar trophoblast cells and shows that the Rlim-Rex1 axis is essential for maintaining their fate and preventing early lethality in female mice.

An ERK5-KLF2 signalling module regulates early embryonic gene expression dynamics and stem cell rejuvenation

This study identifies an ERK5-KLF2 signalling module that regulates 2C gene expression and mESC rejuvenation through both transcriptional activation and phosphorylation-induced degradation of KLF2.

A novel RLIM/RNF12 variant disrupts protein stability and function to cause severe Tonne-Kalscheuer syndrome

This paper identifies a novel RLIM variant causing severe Tonne-Kalscheuer syndrome by disrupting protein stability and function.

A RNF12-USP26 amplification loop promotes germ cell specification and is disrupted in urogenital disorders

The paper identifies a RNF12-USP26 amplification loop critical for germ cell specification and shows its disruption in urogenital disorders.

Functional diversification of Ser-Arg rich protein kinases to control ubiquitin-dependent neurodevelopmental signalling

The paper shows SRPK regulates ubiquitin-dependent neurodevelopmental signalling by phosphorylating RNF12, linking SRPK mutations to intellectual disability.