Robert Gourlay

Kinase-dead controls, XIC quantification and phosphospecific antibodies establish pSer14, pThr156 and pSer418 as NEK1 autophosphorylation sites; a pThr156 assay shows ALS missense variants differ, with R261C reducing it most.

This study shows targeted dephosphorylation of phospho-Tau at the endogenous level promotes its association with microtubules.

This study identifies FAF2 as a strong activator of the p97-UN complex and uses its mechanism to design de novo proteins that enhance p97 activity.

This study identifies NEK7-mediated phosphorylation of cortactin as a mechanism by which EML4-ALK V3 enhances cell migration through actin cytoskeleton remodeling.

The paper identifies SRPK-mediated phosphorylation of MAP1S, showing it regulates proteolytic processing and microtubule binding during neurodevelopment.

This study identifies an ERK5-KLF2 signalling module that regulates 2C gene expression and mESC rejuvenation through both transcriptional activation and phosphorylation-induced degradation of KLF2.

The paper shows SRPK regulates ubiquitin-dependent neurodevelopmental signalling by phosphorylating RNF12, linking SRPK mutations to intellectual disability.