Author

Chaozhe Yang

Children's NationalORCID 0000-0002-5388-7173Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:statistical model· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Lisa M. Guay‐WoodfordiD· 2 shared Naoe HarafujiiD· 2 shared Amar J. MajmundariD· 1 shared Amber K. O’ConnoriD· 1 shared Daniela Anne BrauniD· 1 shared Eva M. Eicher· 1 shared Friedhelm HildebrandtiD· 1 shared Hanan FathyiD· 1 shared

Activity by Year

2021-2023 · peak 1/yr

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10 top collaborators · 30 mutual co-author links

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2 shared papersGenetics

Lisa M. Guay‐WoodfordORCID

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2 papers

Recent·Most cited

Nonsense-associated alternative splicing as a putative reno-protective mechanism in Pkhd1cyli/Pkhd1cyli mutant mice

Chaozhe Yang, Naoe Harafuji, Ljubica Caldovic, Weiying Yu, Ravindra Boddu, Surajit Bhattacharya, Hayk Barseghyan, Heather Gordish‐Dressman, Oded Foreman, Zsuzsanna M. Bebok, Eva M. Eicher, Lisa M. Guay‐Woodford

The paper identifies a frameshift mutation in Pkhd1 causing a cystic liver phenotype in mice and shows alternative splicing leads to reduced Pkhd1 protein levels and attenuated renal cystic disease.

Journal of Molecular Medicine · Aug 16, 2023Peer-reviewedGenetics

Cystin gene mutations cause autosomal recessive polycystic kidney disease associated with altered Myc expression

Chaozhe Yang, Naoe Harafuji, Amber K. O’Connor, Robert A. Kesterson, Jacob A. Watts, Amar J. Majmundar, Daniela Anne Braun, Monkol Lek, Kristen M. Laricchia, Hanan Fathy, Shrikant Mane, Shirlee Shril, Friedhelm Hildebrandt, Lisa M. Guay‐Woodford

This paper shows that Cys1 gene mutations cause ARPKD by altering Myc expression, using mouse models and a human patient case.

Scientific Reports · Sep 14, 2021Peer-reviewedMolecular Biology