Author

Ravindra Boddu

Duke University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:differential expression· 2 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Andrew B. WestiD· 2 shared Nicole Bryant· 2 shared Allison ChangiD· 1 shared Arpine SokratianiD· 1 shared Ashley S. HarmsiD· 1 shared Aubrey M SchonhoffiD· 1 shared Chaozhe YangiD· 1 shared Darren J. MooreiD· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersNeuroscience

Andrew B. WestORCID

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Author profile →

3 papers

Recent·Most cited

Single molecule array measures of LRRK2 kinase activity in serum link Parkinson's disease severity to peripheral inflammation

Yuan Yuan, Huizhong Li, Kashyap Sreeram, Tuyana B. Malankhanova, Ravindra Boddu, Samuel Strader, Allison Chang, Nicole Bryant, Talene A. Yacoubian, David G. Standaert, Madalynn L. Erb, Darren J. Moore, Laurie H. Sanders, Michael William Lutz, Dmitry Velmeshev, Andrew B. West

The paper measures LRRK2 kinase activity via pT73-Rab10 in serum, linking it to inflammation and Parkinson's disease severity.

Molecular Neurodegeneration · Jun 11, 2024Peer-reviewedNeuroscience

Nonsense-associated alternative splicing as a putative reno-protective mechanism in Pkhd1cyli/Pkhd1cyli mutant mice

Chaozhe Yang, Naoe Harafuji, Ljubica Caldovic, Weiying Yu, Ravindra Boddu, Surajit Bhattacharya, Hayk Barseghyan, Heather Gordish‐Dressman, Oded Foreman, Zsuzsanna M. Bebok, Eva M. Eicher, Lisa M. Guay‐Woodford

The paper identifies a frameshift mutation in Pkhd1 causing a cystic liver phenotype in mice and shows alternative splicing leads to reduced Pkhd1 protein levels and attenuated renal cystic disease.

Journal of Molecular Medicine · Aug 16, 2023Peer-reviewedGenetics

Pathologic α-Synuclein Species Activate LRRK2 in Pro-Inflammatory Monocyte and Macrophage Responses

Enquan Xu, Ravindra Boddu, Hisham Abdelmotilib, Kaela Kelly, Arpine Sokratian, Ashley S. Harms, Aubrey M Schonhoff, Nicole Bryant, Irene E. Harmsen, Michael G. Schlossmacher, Sidhanth Chandra, Valentina Krendelshchikova, Zhiyong Liu, Andrew B. West

The paper shows that α-synuclein fibrils activate LRRK2 kinase in monocyte-derived macrophages, linking LRRK2 mutations to pro-inflammatory responses in Parkinson's disease.

bioRxiv · May 4, 2020 · PreprintNeuroscience