BiochemistryStructurePeer-reviewed
Catalytic Mechanism and Differential Alarmone Regulation of a Conserved Stringent Nucleosidase
René L. Bærentsen, Kristina Kronborg, Ditlev Egeskov Brodersen, Yong Everett Zhang
This study investigates how the alarmones ppGpp and pppGpp differentially regulate the nucleosidase PpnN in E. coli, revealing its role in bacterial survival under antibiotic stress and uncovering a conserved catalytic mechanism shared with plant cytokinin signaling proteins.
DOI 10.1016/j.str.2025.10.012