Yong Everett Zhang

This study identifies phage portal proteins as factors that counteract bacterial stringent response by inhibiting alarmone synthetases, revealing a conserved viral strategy to overcome host stress physiology.

The paper shows that basal ppGpp levels in E. coli are actively regulated by SpoT and are essential for metabolic homeostasis and acid resistance.

This study investigates how the alarmones ppGpp and pppGpp differentially regulate the nucleosidase PpnN in E. coli, revealing its role in bacterial survival under antibiotic stress and uncovering a conserved catalytic mechanism shared with plant cytokinin signaling proteins.

The paper investigates the effects of cyclic CMP and UMP on AphA's acid phosphatase activity in Haemophilus influenzae, finding stimulation rather than inhibition.

The paper quantifies the substrate promiscuity of Escherichia coli xanthine oxidase by showing it can use guanine as a substrate, expanding its known metabolic role.

This study shows that E. coli aphA expression increases under carbon and phosphate starvation but decreases with CytR, indicating CytR's repressive role.