Wnt activation in mature dermal adipocytes leads to lipodystrophy and skin fibrosis via ATGL-dependent lipolysis.
Qiannan Ma, Ella X. Segal, Miles A. Montegut, Suneeti R. Madhavan, Anna R. Jussila, Claire Reynolds, Rachel H. Wyetzner, Megan Gregory, Elif G. Ertugral, Chandrasekhar R. Kothapalli, Radhika P. Atit
This study shows that Wnt activation in mature dermal adipocytes causes lipodystrophy and skin fibrosis, which can be reversed by stopping Wnt activation.
The FASEB Journal · Jul 9, 2025Peer-reviewedCell Biology