Radhika P. Atit

Fibronectin 1 is required for suture patency and dysregulated across craniosynostosis models in the mouse

This study investigates the role of Fibronectin 1 in suture patency and its dysregulation in craniosynostosis models in mice, identifying FN1 as a key regulator of calvarial growth and cell differentiation.

Lipodystrophy and recovery are mediated by the Wnt/lipogenesis axis during skin fibrosis.

This study shows that the Wnt/lipogenesis axis mediates lipodystrophy and recovery in skin fibrosis by regulating lipid content and extracellular matrix.

Wnt activation in mature dermal adipocytes leads to lipodystrophy and skin fibrosis via ATGL-dependent lipolysis.

This study shows that Wnt activation in mature dermal adipocytes causes lipodystrophy and skin fibrosis, which can be reversed by stopping Wnt activation.

Mesenchymal Wnts are required for morphogenetic movements of calvarial osteoblasts during apical expansion

This study identifies the role of mesenchymal Wnts in regulating morphogenetic movements of calvarial osteoblasts during apical expansion in mouse embryos.

Apical expansion of calvarial osteoblasts and suture patency is dependent on graded fibronectin cues

This study shows that graded Fibronectin (FN1) cues guide calvarial osteoblast migration and suture patency, with disruptions in FN1 or related pathways causing craniosynostosis in mice.

Wnt-dependent activation of ERK mediates repression of chondrocyte fate during calvarial development.

The paper shows that Wnt and ERK signaling pathways work together to repress Sox9 and control cell fate in cranial mesenchyme during calvarial development.

Dermal EZH2 simultaneously orchestrates dermal differentiation and epidermal proliferation during murine skin development

This study shows dermal EZH2 coordinates dermal fibroblast differentiation and epidermal proliferation during mouse skin development by regulating Wnt/β-catenin and RA signaling.

Oscillatory cortical forces promote three dimensional cell intercalations that shape the mandibular arch

The paper shows that oscillatory cortical forces drive 3D cell intercalations in the mouse mandibular arch, shaping embryonic structures through Wnt5a, YAP/TAZ, and PIEZO1.