Author

Lukas Theo Schmitt

Technische Universität DresdenORCID 0000-0002-5455-4901Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Bioinformatics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:gene regulatory network inference· 2 Approach:deep learning· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein design· 1 Research Focus:software / tool· 1

Frequent Co-Authors

Frank BuchholziD· 2 shared Maciej Paszkowski‐RogacziD· 2 shared Ceren GüneşiD· 1 shared Felix LansingiD· 1 shared Florian JugiD· 1 shared Jan Sonntag· 1 shared Janet KarpinskiiD· 1 shared Jenna HoersteniD· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBioinformatics

Frank BuchholzORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

BioinformaticsNature CommunicationsPeer-reviewedDec 27, 2022

Prediction of designer-recombinases for DNA editing with generative deep learning

Lukas Theo Schmitt, Maciej Paszkowski‐Rogacz, Florian Jug, Frank Buchholz

The paper introduces RecGen, a deep learning model that generates designer-recombinases for novel DNA target sites, outperforming traditional directed evolution methods.

45 citations

deep learningvariational autoencoder

Molecular BiologyNature CommunicationsPeer-reviewedJan 20, 2022

Correction of a Factor VIII genomic inversion with designer-recombinases

Felix Lansing, Liliya Rinatovna Mukhametzyanova, Teresa Rojo Romanos…·Frank Buchholz

This study corrects a 140 kb genomic inversion in the F8 gene using a designer recombinase system, restoring Factor VIII mRNA expression in patient-derived cells.

30 citations

humanDNA methylation