BioinformaticsbioRxivPreprint
From hotspot dependence to distributed robustness in resistance-aware lead optimization
Yuxuan Wang, B Y Xiao, Jingyi Kang…·Weiwei Han
The paper introduces ResistAgent, a framework for resistance-aware lead optimization that converts mutational liabilities into design objectives, improving robustness over average-affinity behavior.
DOI 10.64898/2026.06.16.732538