Author

Silvio E. Perea

Centro de Ingeniería Genética y BiotecnologíaORCID 0000-0002-5791-604XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

B Y Xiao· 1 shared Dongfang Tang· 1 shared Huizi CuiiD· 1 shared Jiale XieiD· 1 shared Jingyi Kang· 1 shared Meifeng WangiD· 1 shared Wan LiuiD· 1 shared Weiwei HaniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBioinformatics

B Y Xiao

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2 papers

Recent·Most cited

From hotspot dependence to distributed robustness in resistance-aware lead optimization

Yuxuan Wang, B Y Xiao, Jingyi Kang, Huizi Cui, Yu Fu, Wen Li, Silvio E. Perea, Weiwei Han

The paper introduces ResistAgent, a framework for resistance-aware lead optimization that converts mutational liabilities into design objectives, improving robustness over average-affinity behavior.

bioRxiv · Jun 22, 2026 · PreprintBioinformatics

CIGB-300 reverses chemo-resistance in MDR1-transfected lung squamous cancer cells

Meifeng Wang, Dongfang Tang, Xiaofang Luo, Wan Liu, Jiale Xie, Ying Yi, Yaqin Lan, Wen Li, Silvio E. Perea, Wubliker Dessie, Yasser Perera, Zuodong Qin

This study shows that CIGB-300 reverses multidrug resistance in ABCB1-overexpressing lung cancer cells by inhibiting ABCB1 expression and related signaling pathways.

bioRxiv · Oct 24, 2024 · PreprintCancer Biology