Author

B Y Xiao

Guangzhou Laboratory

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Bioinformatics· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:C. elegans· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1 Assay:structural biology· 1 Organism:virus· 1

Frequent Co-Authors

David M.J. LilleyiD· 2 shared Jia Wang· 2 shared Mengxiao LiiD· 2 shared Zhichao MiaoiD· 2 shared Buwei HuangiD· 1 shared Éric WesthofiD· 1 shared Huizi CuiiD· 1 shared Jingyi Kang· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersEvolutionary Biology

David M.J. LilleyORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Structural assemblies for an RNA world

Yukun Ren, Zhenglai Zhang, Ke Chen, Mengxiao Li, Yuting Xie, Tiantian Bai, Buwei Huang, B Y Xiao, Éric Westhof, David M.J. Lilley, Jia Wang, Zhichao Miao, Xuepeng Wei, L Huang

The paper shows short RNAs can form complex structures like icosahedrons and filaments, expanding the known RNA quaternary structures and supporting RNA-based self-assembly in an RNA world.

bioRxiv · Jul 1, 2026 · PreprintEvolutionary Biology

From hotspot dependence to distributed robustness in resistance-aware lead optimization

Yuxuan Wang, B Y Xiao, Jingyi Kang, Huizi Cui, Yu Fu, Wen Li, Silvio E. Perea, Weiwei Han

The paper introduces ResistAgent, a framework for resistance-aware lead optimization that converts mutational liabilities into design objectives, improving robustness over average-affinity behavior.

bioRxiv · Jun 22, 2026 · PreprintBioinformatics

The structure and catalytic mechanism of new cellular and viral HDV ribozymes

Yuhang Luo, Xiaoxue Chen, Xiaowei Lin, Wenjian Liao, B Y Xiao, Mengxiao Li, Zhaoji Qiu, Timothy J. Wilson, Zhichao Miao, Jia Wang, Lin Huang, David M.J. Lilley

The paper determines the structure and catalytic mechanism of two new HDV ribozymes from a nematode and a virus, revealing a unique Lewis acid mechanism distinct from other ribozymes.

bioRxiv · Feb 28, 2026 · PreprintBiochemistry