Author

Violetta Steeples

British Heart FoundationORCID 0000-0002-5468-460XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:differential expression· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:genetic perturbation / CRISPR· 1 Assay:metabolomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Hugh C WatkinsiD· 2 shared Alexander J. SparrowiD· 1 shared Animesh AcharjeeiD· 1 shared Arash YavariiD· 1 shared Bernard PrendergastiD· 1 shared Betty RamaniD· 1 shared Charlotte L. Hooper· 1 shared Christopher N. ToepferiD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

Hugh C WatkinsORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintJul 24, 2026

Unmasking Supervillin: SVIL haploinsufficiency causes hypertrophic cardiomyopathy by impairing mechanotransduction and cellular energetics.

Yifan Joshua Li, Yiangos Psaras, Violetta Steeples…·Christopher N. Toepfer

This study identifies SVIL haploinsufficiency as a cause of hypertrophic cardiomyopathy by impairing mechanotransduction and cellular energetics, with potential therapeutic implications for mitochondrial-targeted treatments.

DOI 10.64898/2026.07.01.735949

humanbulk RNA-seq

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Systems BiologybioRxivPreprintOct 13, 2019

Metabolic Profiling of Aortic Stenosis and Hypertrophic Cardiomyopathy Identifies Mechanistic Contrasts in Substrate Utilisation

Nikhil Pal, Animesh Acharjee, Zsuzsanna Ament…·Julian Leether Griffin

This study compares metabolic profiles in aortic stenosis and hypertrophic cardiomyopathy, identifying distinct substrate utilization patterns and PPAR- signaling differences.

3 citations

humanmetabolomics

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