Julian Leether Griffin

This study investigates the role of hepatic HIF2α in MASLD, finding that its deletion leads to extra-hepatic complications like cardiac dysfunction and lean mass loss without protecting against liver disease progression.

The paper describes a participatory workshop approach to strategic planning in healthcare, identifying key themes and actionable strategies through stakeholder input and structured analysis tools.

This study shows that gut microbiota influences liver pathology caused by Schistosoma mansoni infection in mice, but not ileum inflammation.

This study shows that chronic nitrate supplementation in mice with diet-induced obesity worsens metabolic health and accelerates disease progression, including liver cancer.

The paper identifies molecular and metabolic signatures of cardiometabolic syndrome using extreme phenotype groups and shows changes after bariatric surgery.

The paper identifies genetic associations between blood lipid metabolites and cardiometabolic disease loci in South Asian populations using lipidomics data from two studies.

The paper phenotypes Dp1Tyb mice, a Down syndrome model, and identifies multiple DS-like traits including cognitive and physical abnormalities.

This study investigates lipid composition changes in white adipose tissue during obesity, showing distinct effects of lipid storage versus membrane remodeling on cellular function.

This study identifies genetic associations with metabolite levels across multiple cohorts and links these variants to clinical outcomes like type 2 diabetes and macular telangiectasia type 2.

This study compares metabolic profiles in aortic stenosis and hypertrophic cardiomyopathy, identifying distinct substrate utilization patterns and PPAR- signaling differences.

This study shows that microbiota modulates inflammatory responses during CNS demyelination but has little effect on remyelination in mice.