Author

Charlotte L. Hooper

British Heart Foundation

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:mouse· 1

Frequent Co-Authors

Christopher N. ToepferiD· 2 shared Hugh C WatkinsiD· 2 shared Katja GehmlichiD· 2 shared Sophie Broadway‐StringeriD· 2 shared Adam B LokmaniD· 1 shared Alexander J. SparrowiD· 1 shared Amar J. AzadiD· 1 shared Benjamin DaviesiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

Christopher N. ToepferORCID

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3 papers

Recent·Most cited

Unmasking Supervillin: SVIL haploinsufficiency causes hypertrophic cardiomyopathy by impairing mechanotransduction and cellular energetics.

Yifan Joshua Li, Yiangos Psaras, Violetta Steeples, Josephine M Watkins, Charlotte L. Hooper, Marta Moya‐Jódar, T. NICOL, Alexander J. Sparrow, Marcos Garcia-Lacarte, S H Jones, Isabelle Bond, Niklas Beyhoff, Paul Robinson, Marieluise Kirchner, Philipp Mertins, , Christopher N. Toepfer

This study identifies SVIL haploinsufficiency as a cause of hypertrophic cardiomyopathy by impairing mechanotransduction and cellular energetics, with potential therapeutic implications for mitochondrial-targeted treatments.

bioRxiv · Jul 24, 2026 · PreprintCell Biology

An ALPK3 truncation variant causing autosomal dominant hypertrophic cardiomyopathy is partially rescued by mavacamten

Lisa Leinhos, Paul J. Robinson, Giulia Poloni, Sophie Broadway‐Stringer, Julia Beglov, Adam B Lokman, Gillian Douglas, Sajjad Nuthay, Oveena Fonseka, Manuel Schmid, Evie Singer, Charlotte L. Hooper, Kate L. Thomson, Richard D. Bagnall, Jodie Ingles, , Katja Gehmlich

This study identifies an ALPK3 truncation variant causing HCM and shows that mavacamten partially rescues cardiac contractility and calcium handling defects in a mouse model.

Scientific Reports · Mar 24, 2025Peer-reviewedGenetics

Cardiac stress leads to regulation of Filamin C dimerisation via an ancient phosphorylation-modulated interaction with HSPB7

Zihao Wang, Guodong Cao, Miranda P. Collier, Xingyu Qiu, Sophie Broadway‐Stringer, Dominik Šaman, Jediael Z. Y. Ng, Navoneel Sen, Amar J. Azad, Charlotte L. Hooper, Johannes P. Zimmermann, M.A. McDonough, Jürgen Brem, Patrick Rabe, Haigang Song, , Justin L. P. Benesch

The paper investigates how cardiac stress regulates Filamin C dimerisation through phosphorylation-modulated interactions with HSPB7, revealing evolutionary conservation of this mechanism.

bioRxiv · Jan 5, 2024 · PreprintMolecular Biology