Author

Mark Van Doren

Johns Hopkins UniversityORCID 0000-0002-5475-003XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:Drosophila· 6 Research Focus:differential expression· 4 Approach:experimental assay· 4 Approach:statistical model· 4 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2

Frequent Co-Authors

Caitlin PozmanteriD· 3 shared Kelly BaxteriD· 3 shared Cale WhitworthiD· 2 shared Ellen M. Baxter· 1 shared Erin JimeneziD· 1 shared Harrison A. CurnutteiD· 1 shared Hong Zhou· 1 shared Leif BenneriD· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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3 shared papersDevelopmental Biology

Caitlin PozmanterORCID

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Author profile →

7 papers

Recent·Most cited

Steroid signaling controls sex-specific development in an invertebrate

Lydia Grmai, Erin Jimenez, Kelly Baxter, Mark Van Doren

This study shows that in Drosophila, sex-specific ecdysone signaling controls gonad development through cell-autonomous hormone reception, challenging the notion that steroid hormones only regulate development in vertebrates.

bioRxiv · Dec 22, 2023 · PreprintDevelopmental Biology

Tudor domain containing protein 5-like (Tdrd5l) identifies a novel germline body and regulates maternal RNAs during oogenesis

Caitlin Pozmanter, Leif Benner, Sydney E Kelly, Harrison A. Curnutte, Mark Van Doren

This study identifies Tdrd5l as a regulator of maternal RNA translation during oogenesis, showing its role in suppressing translational activators like Orb and maintaining proper dorsal-ventral patterning.

bioRxiv · Aug 2, 2022 · PreprintDevelopmental Biology

Germline Sex Determination regulates sex-specific signaling between germline stem cells and their niche

Pradeep Kumar Bhaskar, Sheryl M. Southard, Kelly Baxter, Mark Van Doren

The paper investigates how germline sex determination regulates signaling between germline stem cells and their niche, showing JAK/STAT signaling promotes male identity while Sex lethal blocks it in XX cells.

Cell Reports · Jan 1, 2021Peer-reviewedDevelopmental Biology

sisterless A is required for activation of Sex lethal in the Drosophila germline

Raghav Goyal, Ellen M. Baxter, Mark Van Doren

This paper identifies sisterless A as an essential activator of Sex lethal in Drosophila germline sex determination, showing it functions similarly to its role in somatic cells.

bioRxiv · Dec 17, 2019 · PreprintDevelopmental Biology

tudor-domain containing protein 5-prime promotes male sexual identity in the Drosophila germline and is repressed in females by Sex lethal

Shekerah Primus, Caitlin Pozmanter, Kelly Baxter, Mark Van Doren

The paper identifies tdrd5p as a gene repressed by Sxl in female Drosophila germ cells and essential for male germline identity and fertility.

PLoS Genetics · Jul 22, 2019Peer-reviewedDevelopmental Biology

fruitless functions downstream of doublesex to promote sexual dimorphism of the gonad stem cell niche

Hong Zhou, Cale Whitworth, Caitlin Pozmanter, Megan C. Neville, Mark Van Doren

This study shows that fruitless (fru) is regulated by doublesex (dsx) in the gonad stem cell niche, promoting sexual dimorphism independently of Transformer-mediated alternative splicing.

bioRxiv · Nov 1, 2018 · PreprintDevelopmental Biology

The creation of sexual dimorphism in Drosophila gonad stem cell niches

Nicole Camara, Cale Whitworth, Mark Van Doren

The paper shows that in Drosophila, gonad stem cell niches can switch between male and female programs in dsx mutants, indicating dsx tips the balance rather than instructs the fate.

bioRxiv · Jul 11, 2018 · PreprintDevelopmental Biology