Hong Zhou

scCircaSim: A Circadian Simulator for Single-Cell and Spatial Transcriptomics

scCircaSim generates circadian single-cell and spatial transcriptomic data with known ground truth to evaluate analysis methods.

A tissue-resolved endothelial surface proteome atlas informs organ-selective vascular targeting

This study maps organ-specific endothelial surface proteomes in vivo to identify tissue-selective vascular targets for therapy.

fruitless functions downstream of doublesex to promote sexual dimorphism of the gonad stem cell niche

This study shows that fruitless (fru) is regulated by doublesex (dsx) in the gonad stem cell niche, promoting sexual dimorphism independently of Transformer-mediated alternative splicing.

Co-adaption of tRNA Gene Copy Number and Amino Acid Usage Influences Translation Rates in Three Life Domains

The paper validates the principle of co-adaptation between tRNA gene copy number and amino acid usage across three life domains, showing it improves translation efficiency in both organisms and individual proteins.

Membrane insertion of- and membrane potential sensing by semiconductor voltage nanosensors: feasibility demonstration

This paper demonstrates semiconductor voltage nanosensors that self-insert into cell membranes and optically record membrane potential with single-particle sensitivity.