Tania Bose

Polyol sugar osmolyte - sorbitol corrects chromosome cohesion and translational defects in cohesin muta

This study shows that sorbitol corrects chromosome cohesion and translational defects in cohesin mutants by reducing ER stress and protein misfolding.

Overexpression of DnaJ chaperones in ameliorating toxicities associated with FUS and TDP-43

This study identifies DnaJ chaperones that reduce toxicity of ALS-related FUS and TDP-43 mutants in yeast by decreasing protein aggregation and slow growth.

Identification of two novel DnaJ chaperone family proteins as modifiers of Huntingtin aggregates

The paper identifies two DnaJ chaperone proteins, CG5001 and P58IPK, that reduce HTT aggregation in HD models, suggesting their potential as therapeutic targets.

Mrj an Hsp40 family chaperone regulates oligomerization of Orb2 and long-term memory

This study identifies Mrj as a chaperone that regulates Orb2A oligomerization, which is essential for long-term memory maintenance in Drosophila.