Repurposing drugs for the prevention of vascular dementia: Evidence from drug target Mendelian randomization
Victoria Taylor‐Bateman, Phazha LK Bothongo, Venexia M. Walker, Patrick G. Kehoe, Liv Tybjærg Nordestgaard, Yoav Ben‐Shlomo, Neil M Davies, Dylan M. Williams, Emma Louise Anderson
This paper uses Mendelian randomization to assess if existing drugs targeting lipid-lowering, anti-hypertensive, or anti-inflammatory pathways affect vascular dementia risk, finding potential benefits for beta-1 adrenergic receptor antagonists and risks for ACE inhibitors.
medRxiv · Apr 11, 2025 · PreprintGenetic & Genomic Medicine