Dylan M. Williams

This study uses Mendelian randomisation to assess if diabetes drug targets affect vascular dementia risk, finding no strong evidence but a suggestive protective effect for DPP4 inhibition.

This study assesses the association between APOE genetic variants and dementia risk in British South Asians using healthcare records and genotyping data.

This paper uses Mendelian randomization to assess if existing drugs targeting lipid-lowering, anti-hypertensive, or anti-inflammatory pathways affect vascular dementia risk, finding potential benefits for beta-1 adrenergic receptor antagonists and risks for ACE inhibitors.

This study uses Mendelian randomization to identify causal risk factors for Alzheimer's disease, finding that education, fluid intelligence, and physical activity are likely causal, while most associations are consequences of early disease.

This study identifies genetic correlations and shared loci between Parkinson disease and inflammatory bowel disease subtypes, highlighting immune-related pathways.

This study performs a genome-wide association study of frailty index to identify genetic signals and pathways, finding synapse function enrichment and associations with educational attainment.

This study identifies 9 novel genetic loci and 215 potential causative genes associated with Alzheimer's disease risk through a large genome-wide association analysis.