Ariel Galindo‐Albarrán

SCITRAM predicts master transcription factors from single-cell transcriptomics data by reconstructing gene regulatory networks and modeling transcriptional cascades.

The paper identifies ZC3H12C as a mediator of CAR-T cell dysfunction in solid tumors through an in vivo CRISPR screen and validates its role using single-cell RNA and ATAC-seq.

The paper shows that mitotic arrest in cancer cells enhances uORF/uoORF translation, leading to increased immunopeptide presentation and T-cell mediated killing.

The paper investigates how RAR-specific agonists drive neuron-astroglia cell fate during stem cell differentiation and brain organoid development, revealing distinct transcriptional signatures and spatial organization.

This paper introduces a computational method to enhance spatial omics resolution by inferring pseudo-interstitial pixels from existing data, validated on spatial transcriptomics datasets.