Upstream open reading frame translation enhances immunogenic peptide presentation in mitotically arrested cancer cells
Alexander Kowar, Jonas Philipp Becker, Rossella Del Pizzo, Zhiwei Tang, Julien Champagne, Kathrin Wellach, Kiana Samimi, Ariel Galindo‐Albarrán, Pierre-René Körner, Jasmine Montenegro Navarro, Andres M. Elia, Fiona Megan Tilghman, Hanan Sakeer, Marco Antonio Mendoza-Parra, Angelika Beate Riemer, , Fabricio Loayza‐Puch
The paper shows that mitotic arrest in cancer cells enhances uORF/uoORF translation, leading to increased immunopeptide presentation and T-cell mediated killing.
Nature Communications · Aug 27, 2025Peer-reviewedCancer Biology