Bryan L. Nathalia

This paper introduces a miRNA feedback circuit to control synthetic receptor activity, showing tunable and autonomous regulation of synNotch receptor expression.

This paper develops a scalable synthetic communication platform for mammalian cells using orthogonal receptors and coiled-coil peptides to enable logic gate computations in cell consortia.

The paper characterizes a synthetic coherent feed-forward loop (CFFL) in E. coli cell-free systems, showing it can repress background activity but is not effective as a temporal filter.