Engineered microRNA feedback circuits enable tunable and autonomous control of synthetic receptor activity
Bryan L. Nathalia, Anna‐Maria Makri Pistikou, Theodorus J. Meuleman, Wilco Nijenhuis, Derin R. Gumustop, Eduardo González-García, Kasey S. Love, Werner Doensen, Anton F. van Galen, Kate E. Galloway, Lukas C. Kapitein, Tom F. A. de Greef
This paper introduces a miRNA feedback circuit to control synthetic receptor activity, showing tunable and autonomous regulation of synNotch receptor expression.
bioRxiv · May 24, 2026 · PreprintSynthetic Biology