Christian Steidl

This study identifies a thymus-specific B-cell differentiation program linked to thymic B-cell lymphomagenesis through single-cell multiomics and spatial profiling.

The paper uses multi-omic single-cell spatial techniques to study FL transformation, finding spatial shifts in B-cell neighborhoods and immunomodulatory interactions linked to disease progression.

This study uses spatial proteomics to reveal immune evasion mechanisms in follicular lymphoma, identifying VISTA and CD14-high follicular dendritic cells as therapeutic targets.

LCR-modules provides a flexible, automated suite of workflows for cancer genome analysis, supporting diverse sequencing types and enabling reproducible, scalable analysis of over 10,800 samples.

The paper identifies self-reactive intra-epithelial plasma cells in ovarian cancer that correlate with improved prognosis and suggest a mechanism for immune response against tumor heterogeneity.

This study identifies four molecular subtypes of Hodgkin lymphoma using multimodal data, revealing distinct clinical features and immune ecosystem dynamics.

This study identifies unique immune environments in DLBCL associated with response to immunotherapy using an integrative multi-omic approach.

ESQmodel evaluates single-cell segmentation quality using expression data and a prior belief of cellular composition to compute per-cell entropy.

The paper uses single-cell sequencing to study the evolution of follicular lymphoma and its microenvironment during transformation, finding gene programs and TME changes associated with progression.

This study identifies genetic drivers of mantle cell lymphoma through exome and genome sequencing, revealing novel mutations in genes involved in RNA splicing and regulation.

CellAssign probabilistically assigns cell types to scRNA-seq data, revealing spatiotemporal dynamics in human cancers like ovarian and follicular lymphoma.

This study identifies somatic coding and regulatory variants in DLBCL, revealing novel mechanisms of oncogene deregulation and potential therapeutic targets.